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Many Cyber-Physical Systems (CPS) have timing constraints that must be met by the cyber components (software and the network) to ensure safety. It is a tedious job to check if a CPS meets its timing requirement especially when it is distributed and the software and/or the underlying computing platforms are complex. Furthermore, the system design is brittle since a timing failure can still happen (e.g., network failure, soft error bit flip). In this article, we propose a new design methodology called Plan B where timing constraints of the CPS are monitored at runtime, and a proper backup routine is executed when a timing failure happens to ensure safety. We provide a model on how to express the desired timing behavior using a set of timing constructs in a C/C++ code and how to efficiently monitor them at the runtime. We showcase the effectiveness of our approach by conducting experiments on three case studies: (1 …