作者
Jacob M Wilson, Samuel C Grant, Sang-Rok Lee, Ihssan S Masad, Young-Min Park, Paul C Henning, Jeffery R Stout, Jeremy P Loenneke, Bahram H Arjmandi, Lynn B Panton, Jeong-Su Kim
发表日期
2012/12
期刊
Journal of the International Society of Sports Nutrition
卷号
9
页码范围
1-11
出版商
BioMed Central
简介
Purpose
To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions.
Methods
Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed.
Results
Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in …
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JM Wilson, SC Grant, SR Lee, IS Masad, YM Park… - Journal of the International Society of Sports Nutrition, 2012