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Powering implanted medical devices (IMDs) is still a challenge since the biological system requires biocompatible, stable, and miniaturized electrical power sources. Making use of the salinity gradient is an attractive and efficient way to generate power. Here, we demonstrate the ion-channel-mimetic negatively charged bacterial cellulose (NBC)/MXene nanofluidic membrane as an osmotic nanopower generator. The introduction of NBC nanofibers into MXene nanosheets brings space charge and enhances ion flux. Considering the in vivo application, saline gelatin hydrogels are used as solid electrolytes for the first time. Benefiting from the combination of one-dimensional (1D) nanofibers and two-dimensional (2D) MXene sheets, a power density of 2.58 W m⁻² is obtained under a 100-fold concentration gradient of solid electrolyte. This work demonstrates that salinity energy conversion can also be achieved using …