作者
James D Chalmers, Stefano Aliberti, Anna Filonenko, Michal Shteinberg, Pieter C Goeminne, Adam T Hill, Thomas C Fardon, Dusanka Obradovic, Christoph Gerlinger, Giovanni Sotgiu, Elisabeth Operschall, Robert M Rutherford, Katerina Dimakou, Eva Polverino, Anthony De Soyza, Melissa J McDonnell
发表日期
2018/6/1
期刊
American journal of respiratory and critical care medicine
卷号
197
期号
11
页码范围
1410-1420
出版商
American Thoracic Society
简介
Rationale: Exacerbations are key events in the natural history of bronchiectasis, but clinical predictors and outcomes of patients with frequently exacerbating disease are not well described.
Objectives: To establish if there is a “frequent exacerbator phenotype” in bronchiectasis and the impact of exacerbations on long-term clinical outcomes.
Methods: We studied patients with bronchiectasis enrolled from 10 clinical centers in Europe and Israel, with up to 5 years of follow-up. Patients were categorized by baseline exacerbation frequency (zero, one, two, or three or more per year). The repeatability of exacerbation status was assessed, as well as the independent impact of exacerbation history on hospitalizations, quality of life, and mortality.
Measurements and Main Results: A total of 2,572 patients were included. Frequent exacerbations were the strongest predictor of future exacerbation frequency, suggesting a …
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JD Chalmers, S Aliberti, A Filonenko, M Shteinberg… - American journal of respiratory and critical care …, 2018