作者
Adam T Hill, Charles S Haworth, Stefano Aliberti, Alan Barker, Francesco Blasi, Wim Boersma, James D Chalmers, Anthony De Soyza, Katerina Dimakou, J Stuart Elborn, Charles Feldman, Patrick Flume, Pieter C Goeminne, Michael R Loebinger, Rosario Menendez, Lucy Morgan, Marlene Murris, Eva Polverino, Alexandra Quittner, Felix C Ringshausen, Gregory Tino, Antoni Torres, Montserrat Vendrell, Tobias Welte, Rob Wilson, Conroy Wong, Anne O'Donnell, Timothy Aksamit
发表日期
2017/6/1
期刊
European Respiratory Journal
卷号
49
期号
6
出版商
European Respiratory Society
简介
There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.
A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.
The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms …
学术搜索中的文章
AT Hill, CS Haworth, S Aliberti, A Barker, F Blasi… - European Respiratory Journal, 2017