作者
David J Llewellyn, Iain A Lang, Kenneth M Langa, Graciela Muniz-Terrera, Caroline L Phillips, Antonio Cherubini, Luigi Ferrucci, David Melzer
发表日期
2010/7/12
期刊
Archives of internal medicine
卷号
170
期号
13
页码范围
1135-1141
出版商
American Medical Association
简介
Background
To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia.
Methods
We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population–based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing.
Results
The multivariate adjusted relative risk (95% confidence …
引用总数
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