作者
Julia Wynn, Usha Krishnan, Gudrun Aspelund, Yuan Zhang, Jimmy Duong, Charles JH Stolar, Eunice Hahn, John Pietsch, Dai Chung, Donald Moore, Eric Austin, George Mychaliska, Robert Gajarski, Yen-Lim Foong, Erik Michelfelder, Douglas Potolka, Brian Bucher, Brad Warner, Mark Grady, Ken Azarow, Scott E Fletcher, Shelby Kutty, Jeff Delaney, Timothy Crombleholme, Erika Rosenzweig, Wendy Chung, Marc S Arkovitz
发表日期
2013/7/1
期刊
The Journal of pediatrics
卷号
163
期号
1
页码范围
114-119. e1
出版商
Mosby
简介
OBJECTIVE
To identify clinical factors associated with pulmonary hypertension (PH) and mortality in patients with congenital diaphragmatic hernia (CDH).
STUDY DESIGN
A prospective cohort of neonates with a diaphragm defect identified at 1 of 7 collaborating medical centers was studied. Echocardiograms were performed at 1 month and 3 months of age and analyzed at a central core by 2 cardiologists independently. Degree of PH and survival were tested for association with clinical variables using Fischer exact test, χ2, and regression analysis.
RESULTS
Two hundred twenty patients met inclusion criteria. Worse PH measured at 1 month of life was associated with higher mortality. Other factors associated with mortality were need for extracorporeal membrane oxygenation, patients inborn at the treating center, and patients with a prenatal diagnosis of CDH. Interestingly, patients with right sided CDH did not …
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J Wynn, U Krishnan, G Aspelund, Y Zhang, J Duong… - The Journal of pediatrics, 2013