作者
Giovanni Targher, Alessandro Mantovani, Isabella Pichiri, Lucia Mingolla, Valentina Cavalieri, William Mantovani, Serena Pancheri, Maddalena Trombetta, Giacomo Zoppini, Michel Chonchol, Christopher D Byrne, Enzo Bonora
发表日期
2014/6/1
期刊
Diabetes care
卷号
37
期号
6
页码范围
1729-1736
出版商
American Diabetes Association
简介
OBJECTIVE
There is no information about the role of nonalcoholic fatty liver disease (NAFLD) in predicting the development of chronic kidney disease (CKD) in type 1 diabetes.
RESEARCH DESIGN AND METHODS
We studied 261 type 1 diabetic adults with preserved kidney function and with no macroalbuminuria at baseline, who were followed for a mean period of 5.2 years for the occurrence of incident CKD (defined as estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2 and/or macroalbuminuria). NAFLD was diagnosed by ultrasonography.
RESULTS
At baseline, patients had a mean eGFR of 92 ± 23 mL/min/1.73 m2; 234 (89.7%) of them had normoalbuminuria and 27 (10.3%) microalbuminuria. NAFLD was present in 131 (50.2%) patients. During follow-up, 61 subjects developed incident CKD. NAFLD was associated with an increased risk of …
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G Targher, A Mantovani, I Pichiri, L Mingolla… - Diabetes care, 2014