作者
Daniel Aletaha, Michael M Ward, Klaus P Machold, Valerie PK Nell, Tanja Stamm, Josef S Smolen
发表日期
2005/9
期刊
Arthritis & Rheumatism
卷号
52
期号
9
页码范围
2625-2636
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Several composite scores are available to assess the activity of rheumatoid arthritis (RA). Criteria for remission and active RA based on these continuous scores are important for use in clinical practice and clinical trials. We aimed to reevaluate or to define such criteria for the Disease Activity Score in 28 joints (DAS28) and the Simplified Disease Activity Index (SDAI).
Methods
We sampled patient profiles from an observational RA database that included clinical and laboratory variables. Thirty‐five rheumatology experts classified these profiles into 1 of 4 categories: remission, low, moderate, or high disease activity. Cutoff values were estimated by mapping scores on the DAS28 and SDAI to these ratings, and analyses of agreement (kappa statistics) and a diagnostic testing approach (receiver operating characteristic curves) were used to validate the estimates. The final criteria were validated using 2 …
引用总数
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