作者
Catherine Hyams, Robin Marlow, Zandile Maseko, Jade King, Lana Ward, Kazminder Fox, Robyn Heath, Anabella Tuner, Zsolt Friedrich, Leigh Morrison, Gabriella Ruffino, Rupert Antico, David Adegbite, Zsuzsa Szasz-Benczur, Maria Garcia Gonzalez, Jennifer Oliver, Leon Danon, Adam Finn
发表日期
2021/11/1
期刊
The Lancet Infectious Diseases
卷号
21
期号
11
页码范围
1539-1548
出版商
Elsevier
简介
Background
On Dec 8, 2020, deployment of the first SARS-CoV-2 vaccination authorised for UK use (BNT162b2 mRNA vaccine) began, followed by an adenoviral vector vaccine ChAdOx1 nCoV-19 on Jan 4, 2021. Care home residents and staff, frontline health-care workers, and adults aged 80 years and older were vaccinated first. However, few data exist regarding the effectiveness of these vaccines in older people with many comorbidities. In this post-implementation evaluation of two COVID-19 vaccines, we aimed to determine the effectiveness of one dose in reducing COVID-19-related admissions to hospital in people of advanced age.
Methods
This prospective test-negative case-control study included adults aged at least 80 years who were admitted to hospital in two NHS trusts in Bristol, UK with signs and symptoms of respiratory disease. Patients who developed symptoms before receiving their vaccine or …
学术搜索中的文章
C Hyams, R Marlow, Z Maseko, J King, L Ward, K Fox… - The Lancet Infectious Diseases, 2021