作者
Francesca Catella-Lawson, Muredach P Reilly, Shiv C Kapoor, Andrew J Cucchiara, Susan DeMarco, Barbara Tournier, Sachin N Vyas, Garret A FitzGerald
发表日期
2001/12/20
期刊
New England Journal of Medicine
卷号
345
期号
25
页码范围
1809-1817
出版商
Massachusetts Medical Society
简介
Background
Patients with arthritis and vascular disease may receive both low-dose aspirin and other nonsteroidal antiinflammatory drugs. We therefore investigated potential interactions between aspirin and commonly prescribed arthritis therapies.
Methods
We administered the following combinations of drugs for six days: aspirin (81 mg every morning) two hours before ibuprofen (400 mg every morning) and the same medications in the reverse order; aspirin two hours before acetaminophen (1000 mg every morning) and the same medications in the reverse order; aspirin two hours before the cyclooxygenase-2 inhibitor rofecoxib (25 mg every morning) and the same medications in the reverse order; enteric-coated aspirin two hours before ibuprofen (400 mg three times a day); and enteric-coated aspirin two hours before delayed-release diclofenac (75 mg twice daily).
Results
Serum thromboxane B2 levels (an …
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