作者
Ernesto S Nakayasu, Lisa M Bramer, Charles Ansong, Athena A Schepmoes, Thomas L Fillmore, Marina A Gritsenko, Therese R Clauss, Yuqian Gao, Paul D Piehowski, Bryan A Stanfill, Dave W Engel, Daniel J Orton, Ronald J Moore, Wei-Jun Qian, Salvatore Sechi, Brigitte I Frohnert, Jorma Toppari, Anette-G Ziegler, Åke Lernmark, William Hagopian, Beena Akolkar, Richard D Smith, Marian J Rewers, Bobbie-Jo M Webb-Robertson, Thomas O Metz
发表日期
2023/7/18
期刊
Cell Reports Medicine
卷号
4
期号
7
出版商
Elsevier
简介
Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 regulated proteins, showing alteration of complement, inflammatory signaling, and metabolic proteins even prior to autoimmunity onset. Extracellular matrix and antigen presentation proteins are differentially regulated in individuals who progress to T1D vs. those that remain in autoimmunity. Targeted proteomics measurements of 167 proteins in 6,426 samples from 990 individuals validate 83 biomarkers. A machine learning analysis predicts if individuals would remain in autoimmunity or develop T1D 6 months before …
学术搜索中的文章
ES Nakayasu, LM Bramer, C Ansong, AA Schepmoes… - Cell Reports Medicine, 2023