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A melamine-based covalent organic framework (COF) nanomaterial, Schiff base network-1 (SNW-1), was incorporated into the polyamide layer of a novel thin film nanocomposite (TFN) pressure retarded osmosis (PRO) membrane. The deposition of SNW-1 was made on an open mesh fabric-reinforced polyamide-imide (PAI) support substrate through interfacial polymerization (IP). SNW-1 loading influence on the water permeability and osmotic power density during PRO operation was investigated. The porous and highly hydrophilic SNW-1 nanomaterial facilitated the flow of water molecules across the membranes, while maintaining satisfactory salt rejection ability of the polyamide selective layer. The membranes exhibited significantly enhanced surface hydrophilicity, water permeability, and power density. The mode of incorporation of SNW-1 during IP was also investigated and it was observed that the …