作者
Stephan Ripke, Colm O'dushlaine, Kimberly Chambert, Jennifer L Moran, Anna K Kähler, Susanne Akterin, Sarah E Bergen, Ann L Collins, James J Crowley, Menachem Fromer, Yunjung Kim, Sang Hong Lee, Patrik KE Magnusson, Nick Sanchez, Eli A Stahl, Stephanie Williams, Naomi R Wray, Kai Xia, Francesco Bettella, Anders D Borglum, Brendan K Bulik-Sullivan, Paul Cormican, Nick Craddock, Christiaan De Leeuw, Naser Durmishi, Michael Gill, Vera Golimbet, Marian L Hamshere, Peter Holmans, David M Hougaard, Kenneth S Kendler, Kuang Lin, Derek W Morris, Ole Mors, Preben B Mortensen, Benjamin M Neale, Francis A O'Neill, Michael J Owen, Milica Pejovic Milovancevic, Danielle Posthuma, John Powell, Alexander L Richards, Brien P Riley, Douglas Ruderfer, Dan Rujescu, Engilbert Sigurdsson, Teimuraz Silagadze, August B Smit, Hreinn Stefansson, Stacy Steinberg, Jaana Suvisaari, Sarah Tosato, Matthijs Verhage, James T Walters, Data and Analysis Group: Spencer Chris CA 82 Band Gavin 82 Bellenguez Céline 82 Freeman Colin 82 Hellenthal Garrett 82 Giannoulatou Eleni 82 Pirinen Matti 82 Pearson Richard D 82 Strange Amy 82 Su Zhan 82 Vukcevic Damjan 82 Donnelly Peter 81 82, Publications Committee: Mathew Christopher G 92 Blackwell Jenefer M 84 85 Brown Matthew A 86 Corvin Aiden P 13 18 McCarthy Mark I 99 Spencer Chris CA 82
发表日期
2013/10
期刊
Nature genetics
卷号
45
期号
10
页码范围
1150-1159
出版商
Nature Publishing Group US
简介
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300–10,200 SNPs) contribute to risk for schizophrenia and that these …
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S Ripke, C O'dushlaine, K Chambert, JL Moran… - Nature genetics, 2013