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Purpose

To elucidate changes in the neurosensory retina in the macular area, using spectral domain OCT and correlate with functional loss on fundus-related microperimetry, in patients with diabetes and no diabetic retinopathy compared with age-matched healthy volunteers.

Methods

This was a prospective study enroling 39 patients in each group. All patients underwent comprehensive dilated eye examination. The foveal thickness and the photoreceptor layer thickness at the foveal centre were measured using spectral domain OCT, and the mean retinal sensitivity of central 20 degrees was measured using microperimetry.

Results

The mean age of the patients with diabetes was 50.92±4.75 years, and of controls, 49.87±5.50 years. SD-OCT measured photoreceptor layer thickness (PLT) to be 61.62±4.48 μm in cases, and 68.79±7.84 μm in controls (P< 0.0001); foveal thickness (FT) was 168.64±16.46 μm in cases …