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A novel statistical feature extraction method, called the neighborhood preserving neural network (NPNN), is proposed in this paper. NPNN can be viewed as a nonlinear data-driven fault detection technique through preserving the local geometrical structure of normal process data. The “local geometrical structure” means that each sample can be constructed as a linear combination of its neighbors. NPNN is characterized by adaptively training a nonlinear neural network which takes the local geometrical structure of the data into consideration. Moreover, in order to extract uncorrelated and faithful features, NPNN adopts orthogonal constraints in the objective function. Through backpropagation and eigen decomposition (ED) technique, NPNN is optimized to extract low-dimensional features from original high-dimensional process data. After nonlinear feature extraction, Hotelling T 2 statistic and the squared prediction …