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At the end of 2019, COVID-19 (Coronavirus 2019) emerged in Wuhan, China, and spread rapidly worldwide. The use of virtual social networks, especially Twitter, has increased due to the present condition. The purpose of the present systematic literature review is to review the investigations on Twitter's role in the COVID-19 crisis. For this purpose, an appropriate search strategy was used to extract the studies conducted in the Web of Science and PubMed databases. In the end, 24 articles were reviewed. The results indicate that in the period of the COVID-19 pandemic, the content and tweets posted on Twitter were affected by this crisis, and various people such as the general public, health professionals, and politicians were sharing opinions, emotions, personal experience, and educational content about exposure to COVID-19 on this social media. Therefore, the speed of providing information to people has been …