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Artificial Intelligence and Analytics (AI&A) are used in various application areas ranging from online entertainment to healthcare. The goal of this Special Issue is to focus on how AI&A are used in practice to assist organisations to create economic value, support decision making, transforming them, and enhance employees’ skills such as communication, innovation, and decision-making. To derive actionable insights on the application of AI&A in practice, the five articles selected for this Special Issue feature both rigorous academic research and reflections and actionable lessons for professionals. This editorial contains a brief overview of the articles included in this special issue.