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Background: Recently, the successful integration of immunotherapy with other treatment modalities has demonstrated its efficacy in enhancing immune activation and suppressing tumors in solid cancers. The most promising of such efforts include the use of low dose radiation (LD-XRT) to prime the tumor microenvironment and enhance the T cell infiltration and activation [Barsoumian HB, et al., 2020; Patel RR, et al., 2021; He K, et al., 2023]. With these advancements, there is an urgent need to develop clinical biomarkers to predict response and optimize treatment decisions. Recent evidence underscores the importance of nanomechanical alterations within the tumor microenvironment as mechanistic indicators of aggressiveness [Plodinec M, et al., 2012]. This study aims to demonstrate the value of ARTIDIS nanomechanical signature as early predictor of elucidate of response to combination LD-XRT/immune …