作者
Francesca Colavita, Daniele Lapa, Fabrizio Carletti, Eleonora Lalle, Francesco Messina, Martina Rueca, Giulia Matusali, Silvia Meschi, Licia Bordi, Patrizia Marsella, Emanuele Nicastri, Luisa Marchioni, Andrea Mariano, Laura Scorzolini, Tommaso Ascoli Bartoli, Antonino Di Caro, Giuseppe Ippolito, Maria Rosaria Capobianchi, Concetta Castilletti
发表日期
2020/10
期刊
Open Forum Infectious Diseases
卷号
7
期号
10
页码范围
ofaa403
出版商
Oxford University Press
简介
Background
The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy.
Methods
We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels.
Results
SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory tract samples. Virus isolate was obtained from acute respiratory samples, while no …
学术搜索中的文章
F Colavita, D Lapa, F Carletti, E Lalle, F Messina… - Open Forum Infectious Diseases, 2020