作者
Matteo D’Antonio, Jennifer P Nguyen, Timothy D Arthur, Hiroko Matsui, Benjamin M Neale, Mark Daly, Andrea Ganna, Christine Stevens, Gita A Pathak, Shea J Andrews, Masahiro Kanai, Mattia Cordioli, Juha Karjalainen, Renato Polimanti, Matti Pirinen, Nadia Harerimana, Kumar Veerapen, Brooke Wolford, Huy Nguyen, Matthew Solomonson, Rachel G Liao, Karolina Chwialkowska, Amy Trankiem, Mary K Balaconis, Caroline Hayward, Anne Richmond, Archie Campbell, Marcela Morris, Chloe Fawns-Ritchie, Joseph T Glessner, Douglas M Shaw, Xiao Chang, Hannah Polikowski, Petty E Lauren, Hung-Hsin Chen, Zhu Wanying, Hakon Hakonarson, David J Porteous, Jennifer Below, Kari North, Joseph B McCormick, Paul RHJ Timmers, James F Wilson, Albert Tenesa, Kenton D’Mellow, Shona M Kerr, Mari EK Niemi, Lindokuhle Nkambul, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M Eltoukhy, Amr M Yassen, Mohamed AF Hegazy, Kamal Okasha, Mohammed A Eid, Hanteera S Moahmed, Doaa Shahin, Yasser M El-Sherbiny, Tamer A Elhadidy, Mohamed S Abd Elghafar, Jehan J El-Jawhari, Attia AS Mohamed, Marwa H Elnagdy, Amr Samir, Mahmoud Abdel-Aziz, Walid T Khafaga, Walaa M El-Lawaty, Mohamed S Torky, Mohamed R El-shanshory, Chiara Batini, Paul H Lee, Nick Shrine, Alexander T Williams, Martin D Tobin, Anna L Guyatt, Catherine John, Richard J Packer, Altaf Ali, Robert C Free, Xueyang Wang, Louise V Wain, Edward J Hollox, Laura D Venn, Catherine E Bee, Emma L Adams, Ahmadreza Niavarani, Bahareh Sharififard, Rasoul Aliannejad, Ali Amirsavadkouhi, Zeinab Naderpour, Hengameh Ansari Tadi, Afshar Etemadi Aleagha, Saeideh Ahmadi, Seyed Behrooz Mohseni Moghaddam, Alireza Adamsara, Morteza Saeedi, Hamed Abdollahi, Abdolmajid Hosseini, Pajaree Chariyavilaskul, Monpat Chamnanphon, Thitima B Suttichet, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Watsamon Jantarabenjakul, Opass Putchareon, Pattama Torvorapanit, Thanyawee Puthanakit, Pintip Suchartlikitwong, Nattiya Hirankarn, Voraphoj Nilaratanakul, Pimpayao Sodsai, Ben M Brumpton, Kristian Hveem, Cristen Willer, Wei Zhou, Tormod Rogne, Erik Solligard, Bjørn Olav Åsvold, Malak Abedalthagafi, Manal Alaamery, Saleh Alqahtani, Dona Baraka, Fawz Al Harthi, Ebtehal Alsolm, Leen Abu Safieh, Albandary M Alowayn, Fatimah Alqubaishi, Amal Al Mutairi, Serghei Mangul, Abdulraheem Alshareef, Mona Sawaji, Mansour Almutairi, Nora Aljawini, Nour Albesher, Yaseen M Arabi, Ebrahim S Mahmoud, Amin K Khattab, Roaa T Halawani, Ziab Z Alahmadey, Jehad K Albakri, Walaa A Felemban, Bandar A Suliman, Rana Hasanato, Laila Al-Awdah, Jahad Alghamdi, Deema AlZahrani, Sameera AlJohani, Hani Al-Afghani
发表日期
2021/11/16
期刊
Cell reports
卷号
37
期号
7
出版商
Elsevier
简介
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed …
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M D'Antonio, JP Nguyen, TD Arthur, H Matsui… - Cell reports, 2021