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Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12. 2 (rs28456, P= 6.4× 10− 9), a region known to contain regulatory genes for plasma lipid levels (FADS1/2/3). A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (P best= 5.8× 10− 10), and supported three regions previously implicated in BD susceptibility: MAD1L1 (P best= 1.9× 10− 9), TRANK1 (P best= 2.1× 10− 9) and ODZ4 (P best= 3.3× 10− 9). Polygenicity of BD within Japanese and trans-European-Japanese populations was …