作者
Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen HM Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman, Joris Deelen, Ko Willems Van Dijk, Tõnu Esko, Jouke-Jan Hottenga, Elisabeth M Van Leeuwen, Terho Lehtimäki, Evelin Mihailov, Richard J Rose, Anton Jm De Craen, Christian Gieger, Mika Kähönen, Markus Perola, Stefan Blankenberg, Markku J Savolainen, Aswin Verhoeven, Jorma Viikari, Gonneke Willemsen, Dorret I Boomsma, Cornelia M Van Duijn, Johan Eriksson, Antti Jula, Marjo-Riitta Järvelin, Jaakko Kaprio, Andres Metspalu, Olli Raitakari, Veikko Salomaa, P Eline Slagboom, Melanie Waldenberger, Samuli Ripatti, Mika Ala-Korpela
发表日期
2016/3/23
期刊
Nature communications
卷号
7
期号
1
页码范围
11122
出版商
Nature Publishing Group UK
简介
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on 123 circulating metabolic traits quantified by nuclear magnetic resonance metabolomics from up to 24,925 individuals and identify eight novel loci for amino acids, pyruvate and fatty acids. The LPA locus link with cardiovascular risk exemplifies how detailed metabolic profiling may inform underlying aetiology via extensive associations with very-low-density lipoprotein and triglyceride metabolism. Genetic fine mapping and Mendelian randomization uncover wide-spread causal effects of …
学术搜索中的文章
J Kettunen, A Demirkan, P Würtz, HHM Draisma… - Nature communications, 2016