作者
Andrea C Wong, Ashwarya S Devason, Iboro C Umana, Timothy O Cox, Lenka Dohnalová, Lev Litichevskiy, Jonathan Perla, Patrick Lundgren, Zienab Etwebi, Luke T Izzo, Jihee Kim, Monika Tetlak, Hélène C Descamps, Simone L Park, Stephen Wisser, Aaron D McKnight, Ryan D Pardy, Junwon Kim, Niklas Blank, Shaan Patel, Katharina Thum, Sydney Mason, Jean-Christophe Beltra, Michaël F Michieletto, Shin Foong Ngiow, Brittany M Miller, Megan J Liou, Bhoomi Madhu, Oxana Dmitrieva-Posocco, Alex S Huber, Peter Hewins, Christopher Petucci, Candice P Chu, Gwen Baraniecki-Zwil, Leila B Giron, Amy E Baxter, Allison R Greenplate, Charlotte Kearns, Kathleen Montone, Leslie A Litzky, Michael Feldman, Jorge Henao-Mejia, Boris Striepen, Holly Ramage, Kellie A Jurado, Kathryn E Wellen, Una O’Doherty, Mohamed Abdel-Mohsen, Alan L Landay, Ali Keshavarzian, Timothy J Henrich, Steven G Deeks, Michael J Peluso, Nuala J Meyer, E John Wherry, Benjamin A Abramoff, Sara Cherry, Christoph A Thaiss, Maayan Levy
发表日期
2023/10/26
期刊
Cell
卷号
186
期号
22
页码范围
4851-4867. e20
出版商
Elsevier
简介
Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction. Here, we propose a mechanism that links all four hypotheses in a single pathway and provides actionable insights for therapeutic interventions. We find that PASC are associated with serotonin reduction. Viral infection and type I interferon-driven inflammation reduce serotonin through three mechanisms: diminished intestinal absorption of the serotonin precursor tryptophan; platelet hyperactivation and thrombocytopenia, which impacts serotonin storage; and enhanced MAO-mediated serotonin turnover. Peripheral serotonin reduction, in turn, impedes the …
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AC Wong, AS Devason, IC Umana, TO Cox… - Cell, 2023