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The mechanistic basis of hepatic dysfunction, a clinically significant complication in malaria, remains largely obscure. Although oxidative stress and associated apoptosis trigger hepatic pathology in a wide variety of infectious and noninfectious diseases, the extent and significance of such events in malaria have not been investigated. The aim of this study was to detect whether malarial infection could lead to oxidative stress and apoptosis in liver of Plasmodium yoelii-infected mice.