作者
Ronadip R Banerjee, Shamina M Rangwala, Jennifer S Shapiro, A Sophie Rich, Ben Rhoades, Yong Qi, Juan Wang, Michael W Rajala, Alessandro Pocai, Phillipp E Scherer, Claire M Steppan, Rexford S Ahima, Silvana Obici, Luciano Rossetti, Mitchell A Lazar
发表日期
2004/2/20
期刊
Science
卷号
303
期号
5661
页码范围
1195-1198
出版商
American Association for the Advancement of Science
简介
The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate–activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.
引用总数
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RR Banerjee, SM Rangwala, JS Shapiro, AS Rich… - Science, 2004