作者
Raphaël Le Bouc, Nicolas Borderies, Guilhem Carle, Chloé Robriquet, Fabien Vinckier, Jean Daunizeau, Carole Azuar, Richard Levy, Mathias Pessiglione
发表日期
2023/2/1
期刊
Brain
卷号
146
期号
2
页码范围
712-726
出版商
Oxford University Press
简介
Apathy is a core symptom in patients with behavioural variant frontotemporal dementia (bvFTD). It is defined by the observable reduction in goal-directed behaviour, but the underlying mechanisms are poorly understood. According to decision theory, engagement in goal-directed behaviour depends on a cost–benefit optimization trading off the estimated effort (related to the behaviour) against the expected reward (related to the goal). In this framework, apathy would thus result from either a decreased appetence for reward, or from an increased aversion to effort. Here, we phenotyped the motivational state of 21 patients with bvFTD and 40 matched healthy controls using computational analyses of behavioural responses in a comprehensive series of behavioural tasks, involving both expression of preference (comparing reward value and effort cost) and optimization of performance (adjusting effort production to …
引用总数
学术搜索中的文章