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Antibodies that bind to c-Met are provided herein, as well as related compositions and methods of use. Methods of use encompass cancer therapies and diagnostics. In certain embodiments, antibodies bind mammalian cell Surface anti gen (eg, cancer cell Surface antigen). The antibodies can also be endocytosed upon binding to cells. Cells that can be tar geted by the antibodies include carcinomas, Such as those in lung, kidney, liver, stomach, breast, and brain, etc. 16 Claims, 14 Drawing Sheets