作者
Lidia S Szczepaniak, Ronald G Victor, Ruchi Mathur, Michael D Nelson, Edward W Szczepaniak, Nicole Tyer, Ida Chen, Roger H Unger, Richard N Bergman, Ildiko Lingvay
发表日期
2012/11/1
期刊
Diabetes care
卷号
35
期号
11
页码范围
2377-2383
出版商
American Diabetes Association
简介
OBJECTIVE
To evaluate racial/ethnic differences in pancreatic triglyceride (TG) levels and their relationship to β-cell dysfunction in humans.
RESEARCH DESIGN AND METHODS
We studied black, Hispanic, and white adults who completed three research visits: screening and an oral glucose tolerance test; frequently sampled intravenous glucose tolerance tests for evaluation of β-cell function and insulin resistance; and proton magnetic resonance spectroscopy for evaluation of pancreatic and hepatic TG levels.
RESULTS
Pancreatic TG levels were higher in Hispanics and whites than in blacks (P = 0.006). Hepatic TG levels were highest in Hispanics (P = 0.004). Compensatory insulin secretion and disposition index were higher in blacks (P = 0.003 and P = 0.024, respectively). Insulin sensitivity was comparable between Hispanics and blacks and was lower …
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LS Szczepaniak, RG Victor, R Mathur, MD Nelson… - Diabetes care, 2012