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This paper presents an approach developed by the Innogen Centre for the analysis of systems of innovation. The approach, developed through the study of innovation in the life sciences, is unique in that it features a triangular view, alongside consideration of the behaviours and interactions between innovators, regulators and policymakers, and advocacy and public interest groups. Furthermore, while the approach can be characterised as co-evolutionary and system-based, it also allows for the user to shift from the macro to micro — considering the impact of institutions on actors and innovation within an institutional milieu, but also considering the individual behaviours and business plans or actions of the actors involved. This paper presents both the approach itself and how the approach was developed.