作者
Robert A Stern, Daniel H Daneshvar, Christine M Baugh, Daniel R Seichepine, Philip H Montenigro, David O Riley, Nathan G Fritts, Julie M Stamm, Clifford A Robbins, Lisa McHale, Irene Simkin, Thor D Stein, Victor E Alvarez, Lee E Goldstein, Andrew E Budson, Neil W Kowall, Christopher J Nowinski, Robert C Cantu, Ann C McKee
发表日期
2013/9/24
期刊
Neurology
卷号
81
期号
13
页码范围
1122-1129
出版商
Lippincott Williams & Wilkins
简介
Objective
The goal of this study was to examine the clinical presentation of chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases.
Methods
Thirty-six adult male subjects were selected from all cases of neuropathologically confirmed CTE at the Boston University Center for the Study of Traumatic Encephalopathy brain bank. Subjects were all athletes, had no comorbid neurodegenerative or motor neuron disease, and had next-of-kin informants to provide retrospective reports of the subjects' histories and clinical presentations. These interviews were conducted blind to the subjects' neuropathologic findings.
Results
A triad of cognitive, behavioral, and mood impairments was common overall, with cognitive deficits reported for almost all subjects. Three subjects were asymptomatic at the time of death. Consistent with earlier case reports of boxers, 2 relatively distinct clinical presentations emerged …
学术搜索中的文章
RA Stern, DH Daneshvar, CM Baugh, DR Seichepine… - Neurology, 2013