作者
Katie A McLaughlin, Margaret A Sheridan, Andrea L Gold, Andrea Duys, Hilary K Lambert, Matthew Peverill, Charlotte Heleniak, Tomer Shechner, Zuzanna Wojcieszak, Daniel S Pine
发表日期
2016/7
期刊
Neuropsychopharmacology
卷号
41
期号
8
页码范围
1956-1964
出版商
Nature Publishing Group
简介
Alterations in learning processes and the neural circuitry that supports fear conditioning and extinction represent mechanisms through which trauma exposure might influence risk for psychopathology. Few studies examine how trauma or neural structure relates to fear conditioning in children. Children (n= 94) aged 6–18 years, 40.4%(n= 38) with exposure to maltreatment (physical abuse, sexual abuse, or domestic violence), completed a fear conditioning paradigm utilizing blue and yellow bells as conditioned stimuli (CS+/CS−) and an aversive alarm noise as the unconditioned stimulus. Skin conductance responses (SCR) and self-reported fear were acquired. Magnetic resonance imaging data were acquired from 60 children. Children without maltreatment exposure exhibited strong differential conditioning to the CS+ vs CS−, based on SCR and self-reported fear. In contrast, maltreated children exhibited blunted …
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KA McLaughlin, MA Sheridan, AL Gold, A Duys… - Neuropsychopharmacology, 2016