作者
Hugh Montgomery, Peter Clarkson, Maria Barnard, Jimmy Bell, Audrey Brynes, Joseph Hajnal, Harry Hemingway, Dawn Mercer, Paul Jarman, Richard Marshall, Krishna Prasad, Mark Rayson, Nadeem Saeed, Louise Thomas, Mick Jubb, Claire Dollery, Phillipa Talmud, Steve Humphries
发表日期
1999/2/13
期刊
The Lancet
卷号
353
期号
9152
页码范围
541-545
出版商
Elsevier
简介
Background
The function of local renin-angiotensin systems in skeletal muscle and adipose tissue remains largely unknown. A polymorphism of the human angiotensin converting enzyme (ACE) gene has been identified in which the insertion (I) rather than deletion (D) allele is associated with lower ACE activity in body tissues and increased response to some aspects of physical training. We studied the association between the ACE gene insertion or deletion polymorphism and changes in body composition related to an intensive exercise programme, to investigate the metabolic effects of local human renin-angiotensin systems.
Methods
We used three independent methods (bioimpedance, multiple skinfold-thickness assessment of whole-body composition, magnetic resonance imaging of the mid-thigh) to study changes in body composition in young male army recruits over 10 weeks of intensive physical training …
引用总数
学术搜索中的文章
Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training
H Montgomery, P Clarkson, M Barnard, J Bell, A Brynes… - The Lancet, 1999