作者
Emerson C Perin, Guilherme V Silva, Timothy D Henry, Maria G Cabreira-Hansen, Warren H Moore, Stephanie A Coulter, J Patrick Herlihy, Marlos R Fernandes, Benjamin YC Cheong, Scott D Flamm, Jay H Traverse, Yi Zheng, Deirdre Smith, Sandi Shaw, Lynette Westbrook, Rachel Olson, Dipsu Patel, Amir Gahremanpour, John Canales, William K Vaughn, James T Willerson
发表日期
2011/6/1
期刊
American heart journal
卷号
161
期号
6
页码范围
1078-1087. e3
出版商
Mosby
简介
Background
Autologous bone marrow mononuclear cell (ABMMNC) therapy has shown promise in patients with heart failure (HF). Cell function analysis may be important in interpreting trial results.
Methods
In this prospective study, we evaluated the safety and efficacy of the transendocardial delivery of ABMMNCs in no-option patients with chronic HF. Efficacy was assessed by maximal myocardial oxygen consumption, single photon emission computed tomography, 2-dimensional echocardiography, and quality-of-life assessment (Minnesota Living with Heart Failure and Short Form 36). We also characterized patients' bone marrow cells by flow cytometry, colony-forming unit, and proliferative assays.
Results
Cell-treated (n = 20) and control patients (n = 10) were similar at baseline. The procedure was safe; adverse events were similar in both groups. Canadian Cardiovascular Society angina score improved …
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EC Perin, GV Silva, TD Henry, MG Cabreira-Hansen… - American heart journal, 2011