作者
Gregory L Calligaro, Grant Theron, Hoosain Khalfey, Jonathan Peter, Richard Meldau, Brian Matinyenya, Malika Davids, Liezel Smith, Anil Pooran, Maia Lesosky, Aliasgar Esmail, Malcolm G Miller, Jenna Piercy, Lancelot Michell, Rodney Dawson, Richard I Raine, Ivan Joubert, Keertan Dheda
发表日期
2015/8/1
期刊
The lancet Respiratory medicine
卷号
3
期号
8
页码范围
621-630
出版商
Elsevier
简介
Background
There are few prospective data about the incidence and mortality associated with pulmonary tuberculosis in intensive care units (ICUs), and none on the accuracy and clinical effect of the Xpert-MTB/RIF assay in this setting. We aimed to measure the frequency of culture-positive tuberculosis in ICUs in Cape Town, South Africa and to assess the performance and effect on patient outcomes of Xpert MTB/RIF versus smear microscopy for diagnosis of tuberculosis.
Methods
We did a prospective burden of disease study with a randomised controlled substudy at the ICUs of four hospitals in Cape Town. Mechanically ventilated adults (≥18 years) with suspected pulmonary tuberculosis admitted between Aug 1, 2010, and July 31, 2013 (irrespective of the reason for admission), were prospectively investigated by culture, and by Xpert-MTB/RIF testing or smear microscopy, of tracheal aspirate samples. In the …
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GL Calligaro, G Theron, H Khalfey, J Peter, R Meldau… - The lancet Respiratory medicine, 2015