作者
Shehzad Basaria, Andrea D Coviello, Thomas G Travison, Thomas W Storer, Wildon R Farwell, Alan M Jette, Richard Eder, Sharon Tennstedt, Jagadish Ulloor, Anqi Zhang, Karen Choong, Kishore M Lakshman, Norman A Mazer, Renee Miciek, Joanne Krasnoff, Ayan Elmi, Philip E Knapp, Brad Brooks, Erica Appleman, Sheetal Aggarwal, Geeta Bhasin, Leif Hede-Brierley, Ashmeet Bhatia, Lauren Collins, Nathan LeBrasseur, Louis D Fiore, Shalender Bhasin
发表日期
2010/7/8
期刊
New England Journal of Medicine
卷号
363
期号
2
页码范围
109-122
出版商
Massachusetts Medical Society
简介
Background
Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied.
Methods
Community-dwelling men, 65 years of age or older, with limitations in mobility and a total serum testosterone level of 100 to 350 ng per deciliter (3.5 to 12.1 nmol per liter) or a free serum testosterone level of less than 50 pg per milliliter (173 pmol per liter) were randomly assigned to receive placebo gel or testosterone gel, to be applied daily for 6 months. Adverse events were categorized with the use of the Medical Dictionary for Regulatory Activities classification. The data and safety monitoring board recommended that the trial be discontinued early because there was a significantly higher rate of adverse cardiovascular events in the testosterone group than in the …
引用总数
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S Basaria, AD Coviello, TG Travison, TW Storer… - New England Journal of Medicine, 2010