作者
Thomas G Travison, Shehzad Basaria, Thomas W Storer, Alan M Jette, Renee Miciek, Wildon R Farwell, Karen Choong, Kishore Lakshman, Norman A Mazer, Andrea D Coviello, Philip E Knapp, Jagadish Ulloor, Anqi Zhang, Brad Brooks, Ahn-Hoa Nguyen, Richard Eder, Nathan LeBrasseur, Ayan Elmi, Erica Appleman, Leife Hede-Brierley, Geeta Bhasin, Ashmeet Bhatia, Antonio Lazzari, Samuel Davis, Pengsheng Ni, Lauren Collins, Shalender Bhasin
发表日期
2011/10/1
期刊
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
卷号
66
期号
10
页码范围
1090-1099
出版商
Oxford University Press
简介
Context
Testosterone in Older Men with Mobility Limitations Trial determined the effects of testosterone on muscle performance and physical function in older men with mobility limitation. Trial’s Data and Safety Monitoring Board recommended enrollment cessation due to increased frequency of adverse events in testosterone arm. The changes in muscle performance and physical function were evaluated in relation to participant’s perception of change.
Methods
Men aged 65 years and older, with mobility limitation, total testosterone 100–350 ng/dL, or free testosterone less than 50 pg/mL, were randomized to placebo or 10 g testosterone gel daily for 6 months. Primary outcome was leg-press strength. Secondary outcomes included chest-press strength, stair-climb, 40-m walk, muscle mass, physical activity, self-reported function, and fatigue. Proportions of participants exceeding …
学术搜索中的文章
TG Travison, S Basaria, TW Storer, AM Jette, R Miciek… - Journals of Gerontology Series A: Biomedical Sciences …, 2011