作者
Carolyn SP Lam, Susan Cheng, Karen Choong, Martin G Larson, Joanne M Murabito, Christopher Newton-Cheh, Shalender Bhasin, Elizabeth L McCabe, Karen K Miller, Margaret M Redfield, Ramachandran S Vasan, Andrea D Coviello, Thomas J Wang
发表日期
2011/8/2
期刊
Journal of the American College of Cardiology
卷号
58
期号
6
页码范围
618-626
出版商
American College of Cardiology Foundation
简介
Objectives
The aim of this study was to assess the relationship between sex hormones and natriuretic peptide levels in community-based adults.
Background
Women have higher circulating natriuretic peptide concentrations than men, but the mechanisms for these sex-related differences and the impact of hormone therapy are unclear. Experimental studies suggest that androgens may suppress natriuretic peptide secretion.
Methods
We measured N-terminal pro–B-type natriuretic peptide (NT-proBNP), total testosterone, and sex hormone–binding globulin plasma levels in 4,056 men and women (mean age 40 ± 9 years) from the Framingham Heart Study Third-Generation cohort. Sex/hormone status was grouped as: 1) men; 2) post-menopausal women not receiving hormone replacement therapy; 3) pre-menopausal women not receiving hormonal contraceptives; 4) post-menopausal women receiving hormone …
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CSP Lam, S Cheng, K Choong, MG Larson… - Journal of the American College of Cardiology, 2011