作者
Shalender Bhasin, Michael Pencina, Guneet Kaur Jasuja, Thomas G Travison, Andrea Coviello, Eric Orwoll, Patty Y Wang, Carrie Nielson, Frederick Wu, Abdelouahid Tajar, Fernand Labrie, Hubert Vesper, Anqi Zhang, Jagadish Ulloor, Ravinder Singh, Ralph D'Agostino, Ramachandran S Vasan
发表日期
2011/8/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
96
期号
8
页码范围
2430-2439
出版商
Oxford University Press
简介
Context
Reference ranges are essential for partitioning testosterone levels into low or normal and making the diagnosis of androgen deficiency. We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men.
Methods
TT was measured using liquid chromatography tandem mass spectrometry in nonobese healthy men, 19–40 yr old, in the Framingham Heart Study Generation 3; FT was calculated. Values below the 2.5th percentile of reference sample were deemed low. We determined the association of low TT and FT with physical dysfunction, sexual symptoms [European Male Aging Study (EMAS) only], and diabetes mellitus in three cohorts: Framingham Heart Study generations 2 and 3, EMAS, and the Osteoporotic Fractures in Men Study.
Results
In a reference sample of 456 men, mean (sd …
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S Bhasin, M Pencina, GK Jasuja, TG Travison… - The Journal of Clinical Endocrinology & Metabolism, 2011