作者
Shehzad Basaria, S Mitchell Harman, Thomas G Travison, Howard Hodis, Panayiotis Tsitouras, Matthew Budoff, Karol M Pencina, Joseph Vita, Connie Dzekov, Norman A Mazer, Andrea D Coviello, Philip E Knapp, Kathleen Hally, Emma Pinjic, Mingzhu Yan, Thomas W Storer, Shalender Bhasin
发表日期
2015/8/11
期刊
Jama
卷号
314
期号
6
页码范围
570-581
出版商
American Medical Association
简介
Importance
Testosterone use in older men is increasing, but its long-term effects on progression of atherosclerosis are unknown.
Objective
To determine the effect of testosterone administration on subclinical atherosclerosis progression in older men with low or low-normal testosterone levels.
Design, Setting, and Participants
Testosterone’s Effects on Atherosclerosis Progression in Aging Men (TEAAM) was a placebo-controlled, double-blind, parallel-group randomized trial involving 308 men 60 years or older with low or low-normal testosterone levels (100-400 ng/dL; free testosterone <50 pg/mL), recruited at 3 US centers. Recruitment took place between September 2004 and February 2009; the last participant completed the study in May 2012.
Interventions
One hundred fifty-six participants were randomized to receive 7.5 g of 1% testosterone and 152 were randomized to receive placebo gel packets daily for 3 years …
学术搜索中的文章
S Basaria, SM Harman, TG Travison, H Hodis… - Jama, 2015