作者
Abigail May Khan, Susan Cheng, Martin Magnusson, Martin G Larson, Christopher Newton-Cheh, Elizabeth L McCabe, Andrea D Coviello, Jose C Florez, Caroline S Fox, Daniel Levy, Sander J Robins, Pankaj Arora, Shalender Bhasin, Carolyn SP Lam, Ramachandran S Vasan, Olle Melander, Thomas J Wang
发表日期
2011/10/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
96
期号
10
页码范围
3242-3249
出版商
Oxford University Press
简介
Background
The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation. It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown.
Aim
The aim of this study was to examine the association between obesity and natriuretic peptide levels and evaluate the role of hyperinsulinemia and testosterone as mediators of this interaction.
Methods
We studied 7770 individuals from the Framingham Heart Study (n = 3833, 54% women) and the Malmö Diet and Cancer study (n = 3918, 60% women). We examined the relation of plasma N-terminal pro-B-type natriuretic peptide levels (N-BNP) with obesity, insulin resistance, and various metabolic subtypes.
Results
Obesity was associated with 6–20% lower …
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AM Khan, S Cheng, M Magnusson, MG Larson… - The Journal of Clinical Endocrinology & Metabolism, 2011