作者
Joanne B Krasnoff, Shehzad Basaria, Michael J Pencina, Guneet K Jasuja, Ramachandran S Vasan, Jagadish Ulloor, Anqi Zhang, Andrea Coviello, Margaret Kelly-Hayes, Ralph B D'Agostino, Philip A Wolf, Shalender Bhasin, Joanne M Murabito
发表日期
2010/6/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
95
期号
6
页码范围
2790-2799
出版商
Oxford University Press
简介
Context: Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood.
Objective: Our objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men.
Design, Setting, and Participants: We conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 ± 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectional and longitudinal analyses of mobility limitation and physical performance were performed with continuous (per sd) and dichotomized [low TT …
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JB Krasnoff, S Basaria, MJ Pencina, GK Jasuja… - The Journal of Clinical Endocrinology & Metabolism, 2010