作者
Marco Rossi, Gabriele Sganga, Marinella Mazzone, Venanzio Valenza, Sergio Guarneri, Grazia Portale, Luigi Carbone, Lucia Gatta, Claudio Pioli, Maurizio Sanguinetti, Massimo Montalto, Franco Glieca, Giovanni Fadda, Rocco Schiavello, Nicolò G Silveri
发表日期
2004/2/1
期刊
The Annals of thoracic surgery
卷号
77
期号
2
页码范围
612-618
出版商
Elsevier
简介
BACKGROUND
Cardiopulmonary bypass provokes a systemic inflammatory reaction that, in 1% to 2% of all cases, leads to multiorgan disfunction. The aim of this study was to evaluate the possible role of the intestine in the pathogenesis and development of this reaction.
METHODS
Eleven selected patients scheduled for elective coronary artery bypass graft surgery were enrolled in a open, prospective clinical study. Gastric tonometry, chromium-labeled test and double sugar intestinal absorption tests, polymerase chain reaction microbial DNA test, and measurement of cytokines and transcriptional factor (nuclear factor κB) activation were performed.
RESULTS
During the postoperative period, gastric pH remained stable (range,7.2 to 7.3). The partial pressure for carbon dioxide gradient between the gastric mucosa and arterial blood increased significantly (from 1 to 23 mm Hg), peaking in the sixth postoperative …
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M Rossi, G Sganga, M Mazzone, V Valenza… - The Annals of thoracic surgery, 2004