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Triply Periodic Minimal Surface (TPMS) porous structures are recognized as the most promising bionic artificial structures for tissue engineering. The fatigue properties of additive manufactured porous structures are essential for long-term use in a dynamical bio-skeletal environment. The aim of this study is to study the compression–compression fatigue behaviour and the underlying fatigue mechanism of Gyroid cellular structures (GCS), a typical TPMS porous structure. The high-cycle fatigue results show that both cyclic ratcheting and fatigue damage phenomena contribute to the failure of GCS during fatigue testing. For most fatigue loading stress, the failure samples have nearly 45° fracture bands along the diagonal surface. The fatigue ratio of GCS reaches 0.35 for as-built samples and can be raised to 0.45 after sandblasting treatment. The fatigue ratio values are higher than most of the other bending-dominated …