作者
L Cetina, A González-Enciso, D Cantú, J Coronel, D Pérez-Montiel, J Hinojosa, A Serrano, L Rivera, A Poitevin, A Mota, E Trejo, G Montalvo, D Muñoz, J Robles-Flores, J De La Garza, J Chanona, R Jiménez-Lima, T Wegman, A Dueñas-González
发表日期
2013/8/1
期刊
Annals of oncology
卷号
24
期号
8
页码范围
2043-2047
出版商
Elsevier
简介
Background
The aim of the present study was to demonstrate that radical hysterectomy (RH) leads to improved survival outcomes in FIGO stage IB2–IIB cervical cancer when compared with standard brachytherapy (BCT) after identical external beam chemoradiation (EBRT-CT).
Patients and methods
EBRT-CT treatment consisted of six courses of cisplatin at 40 mg/m2 and gemcitabine at 125 mg/m2 per week concurrent with 50.4 Gy of radiation. In the BCT arm, EBRT-CT was followed by BCT to reach a point A dose of 85 Gy, whereas in the experimental arm, a type III RH with bilateral pelvic lymph node dissection and para-aortic lymph node sampling (RH) was carried out within 4–6 weeks after EBRT-CT.
Results
Between May 2004 and June 2009, 211 patients were enrolled (BCT, 100 and RH, 111). At a median follow-up time of 36 months (3–80), progression-free survival (PFS) and overall survival (OS) rates were …
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L Cetina, A González-Enciso, D Cantú, J Coronel… - Annals of oncology, 2013