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The BBIBP-CorV severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivated vaccine has been authorized for emergency use and widely distributed. We used single-cell transcriptome sequencing to characterize the dynamics of immune responses to the BBIBP-CorV inactivated vaccine. In addition to the expected induction of humoral immunity, we found that the inactivated vaccine induced multiple, comprehensive immune responses, including significantly increased proportions of CD16⁺ monocytes and activation of monocyte antigen presentation pathways; T cell activation pathway upregulation in CD8⁺ T cells, along with increased activation of CD4⁺ T cells; significant enhancement of cell-cell communications between innate and adaptive immunity; and the induction of regulatory CD4⁺ T cells and co-inhibitory interactions to maintain immune homeostasis after vaccination. Additionally …