作者
Carole L Marcus, Lisa J Meltzer, Robin S Roberts, Joel Traylor, Joanne Dix, Judy D’ilario, Elizabeth Asztalos, Gillian Opie, Lex W Doyle, Sarah N Biggs, Gillian M Nixon, Indra Narang, Rakesh Bhattacharjee, Margot Davey, Rosemary SC Horne, Maureen Cheshire, Jeremy Gibbons, Lorrie Costantini, Ruth Bradford, Barbara Schmidt
发表日期
2014/10/1
期刊
American journal of respiratory and critical care medicine
卷号
190
期号
7
页码范围
791-799
出版商
American Thoracic Society
简介
Rationale: Apnea of prematurity is a common condition that is usually treated with caffeine, an adenosine receptor blocker that has powerful influences on the central nervous system. However, little is known about the long-term effects of caffeine on sleep in the developing brain.
Objectives: We hypothesized that neonatal caffeine use resulted in long-term abnormalities in sleep architecture and breathing during sleep.
Methods: A total of 201 ex-preterm children aged 5–12 years who participated as neonates in a double-blind, randomized, controlled clinical trial of caffeine versus placebo underwent actigraphy, polysomnography, and parental sleep questionnaires. Coprimary outcomes were total sleep time on actigraphy and apnea–hypopnea index on polysomnography.
Measurements and Main Results: There were no significant differences in primary outcomes between the caffeine group and the placebo (adjusted …
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CL Marcus, LJ Meltzer, RS Roberts, J Traylor, J Dix… - American journal of respiratory and critical care …, 2014