作者
Megan R Sutherland, Lina Gubhaju, Lynette Moore, Alison L Kent, Jane E Dahlstrom, Rosemary SC Horne, Wendy E Hoy, John F Bertram, M Jane Black
发表日期
2011/7/1
期刊
Journal of the American Society of Nephrology
卷号
22
期号
7
页码范围
1365-1374
出版商
LWW
简介
Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone, number of glomerular generations, cross-sectional area of the renal corpuscle, and glomerular maturity and morphology. Renal maturation accelerated after preterm birth, with an increased number of glomerular generations and a decreased width of the nephrogenic zone in the kidneys of preterm neonates. Of particular concern, compared with gestational controls, preterm kidneys had a greater percentage of …
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MR Sutherland, L Gubhaju, L Moore, AL Kent… - Journal of the American Society of Nephrology, 2011