作者
Michael A Williams, Amy J McGowan, Chris R Cardwell, Carol Y Cheung, David Craig, Peter Passmore, Giuliana Silvestri, Alexander P Maxwell, Gareth J McKay
发表日期
2015/6/1
期刊
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
卷号
1
期号
2
页码范围
229-235
出版商
No longer published by Elsevier
简介
Introduction
Cerebral small-vessel disease has been implicated in the development of Alzheimer's disease (AD). The retinal microvasculature enables the noninvasive visualization and evaluation of the systemic microcirculation. We evaluated retinal microvascular parameters in a case-control study of AD patients and cognitively normal controls.
Methods
Retinal images were computationally analyzed and quantitative retinal parameters (caliber, fractal dimension, tortuosity, and bifurcation) measured. Regression models were used to compute odds ratios (OR) and confidence intervals (CI) for AD with adjustment for confounders.
Results
Retinal images were available in 213 AD participants and 294 cognitively normal controls. Persons with lower venular fractal dimension (OR per standard deviation [SD] increase, 0.77 [CI: 0.62–0.97]) and lower arteriolar tortuosity (OR per SD increase, 0.78 [CI: 0.63–0.97]) were more …
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MA Williams, AJ McGowan, CR Cardwell, CY Cheung… - Alzheimer's & Dementia: Diagnosis, Assessment & …, 2015