作者
Gareth J McKay, Giuliana Silvestri, Usha Chakravarthy, Shilpa Dasari, Lars G Fritsche, Bernhard H Weber, Claudia N Keilhauer, Michael L Klein, Peter J Francis, Caroline C Klaver, Johannes R Vingerling, Lintje Ho, Paulus TDV De Jong, Michael Dean, Julie Sawitzke, Paul N Baird, Robyn H Guymer, Dwight Stambolian, Anton Orlin, Johanna M Seddon, Inga Peter, Alan F Wright, Caroline Hayward, Andrew J Lotery, Sarah Ennis, Michael B Gorin, Daniel E Weeks, Chia-Ling Kuo, Aroon D Hingorani, Reecha Sofat, Valentina Cipriani, Anand Swaroop, Mohammad Othman, Atsuhiro Kanda, Wei Chen, Goncalo R Abecasis, John R Yates, Andrew R Webster, Anthony T Moore, Johan H Seland, Mati Rahu, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Jesus Vioque, Ian S Young, Astrid E Fletcher, Chris C Patterson
发表日期
2011/6/15
来源
American journal of epidemiology
卷号
173
期号
12
页码范围
1357-1364
出版商
Oxford University Press
简介
Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms ε2, ε3, and ε4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD. In an analysis stratified by study center, gender, and smoking status, there was a decreasing frequency of the APOE ε4 isoform with increasing age (χ2 for trend = 14.9 (1 df); P = 0.0001), with a concomitant increase in the ε3 isoform (χ2 for trend = 11.3 (1 df); P = 0.001). The association with age was strongest in ε4 homozygotes; the …
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GJ McKay, G Silvestri, U Chakravarthy, S Dasari… - American journal of epidemiology, 2011